Cargando…

A tryptophan residue in the caffeine-binding site of the ryanodine receptor regulates Ca(2+) sensitivity

Ryanodine receptors (RyRs) are Ca(2+) release channels in the sarcoplasmic reticulum of skeletal and cardiac muscles and are essential for muscle contraction. Mutations in genes encoding RyRs cause various muscle and arrhythmogenic heart diseases. Although RyR channels are activated by Ca(2+), the a...

Descripción completa

Detalles Bibliográficos
Autores principales:	Murayama, Takashi, Ogawa, Haruo, Kurebayashi, Nagomi, Ohno, Seiko, Horie, Minoru, Sakurai, Takashi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6123685/ https://www.ncbi.nlm.nih.gov/pubmed/30271978 http://dx.doi.org/10.1038/s42003-018-0103-x

Ejemplares similares

Regulatory mechanisms of ryanodine receptor/Ca(2+) release channel revealed by recent advancements in structural studies
por: Ogawa, Haruo, et al.
Publicado: (2020)

Extensive Ca(2+) leak through K4750Q cardiac ryanodine receptors caused by cytosolic and luminal Ca(2+) hypersensitivity
por: Uehara, Akira, et al.
Publicado: (2017)

Cytosolic Ca(2+)-dependent Ca(2+) release activity primarily determines the ER Ca(2+) level in cells expressing the CPVT-linked mutant RYR2
por: Kurebayashi, Nagomi, et al.
Publicado: (2022)

Molecular basis for gating of cardiac ryanodine receptor explains the mechanisms for gain- and loss-of function mutations
por: Kobayashi, Takuya, et al.
Publicado: (2022)

The Ryanodine Receptor as a Sensor for Intracellular Environments in Muscles
por: Kobayashi, Takuya, et al.
Publicado: (2021)

Divergent Activity Profiles of Type 1 Ryanodine Receptor Channels Carrying Malignant Hyperthermia and Central Core Disease Mutations in the Amino-Terminal Region
por: Murayama, Takashi, et al.
Publicado: (2015)

Insights into channel modulation mechanism of RYR1 mutants using Ca(2+) imaging and molecular dynamics
por: Yamazawa, Toshiko, et al.
Publicado: (2019)

Heat-hypersensitive mutants of ryanodine receptor type 1 revealed by microscopic heating
por: Oyama, Kotaro, et al.
Publicado: (2022)

Structural and functional interactions between the Ca(2+)-, ATP-, and caffeine-binding sites of skeletal muscle ryanodine receptor (RyR1)
por: Chirasani, Venkat R., et al.
Publicado: (2021)

Structural mechanism of two gain-of-function cardiac and skeletal RyR mutations at an equivalent site by cryo-EM
por: Iyer, Kavita A., et al.
Publicado: (2020)

A reconstituted depolarization-induced Ca(2+) release platform for validation of skeletal muscle disease mutations and drug discovery
por: Murayama, Takashi, et al.
Publicado: (2022)

Frog α- and β-Ryanodine Receptors Provide Distinct Intracellular Ca(2+) Signals in a Myogenic Cell Line
por: Kashiyama, Taku, et al.
Publicado: (2010)

Caffeine- and ryanodine-sensitive Ca(2+)-induced Ca2+ release from the endoplasmic reticulum in honeybee photoreceptors
Publicado: (1995)

Engineering a Novel Multifunctional Green Fluorescent Protein Tag for a Wide Variety of Protein Research
por: Kobayashi, Takuya, et al.
Publicado: (2008)

Long‐term, but not short‐term high‐fat diet induces fiber composition changes and impaired contractile force in mouse fast‐twitch skeletal muscle
por: Eshima, Hiroaki, et al.
Publicado: (2017)

Inositol 1,4,5‐trisphosphate receptor determines intracellular Ca(2+) concentration in Trypanosoma cruzi throughout its life cycle
por: Hashimoto, Muneaki, et al.
Publicado: (2016)

Usefulness of Running Wheel for Detection of Congestive Heart Failure in Dilated Cardiomyopathy Mouse Model
por: Sugihara, Masami, et al.
Publicado: (2013)

Multistep Ion Channel Remodeling and Lethal Arrhythmia Precede Heart Failure in a Mouse Model of Inherited Dilated Cardiomyopathy
por: Suzuki, Takeshi, et al.
Publicado: (2012)

Effects of Candesartan on Electrical Remodeling in the Hearts of Inherited Dilated Cardiomyopathy Model Mice
por: Odagiri, Fuminori, et al.
Publicado: (2014)

Causes of Abnormal Ca(2+) Transients in Guinea Pig Pathophysiological Ventricular Muscle Revealed by Ca(2+) and Action Potential Imaging at Cellular Level
por: Nishizawa, Hiroto, et al.
Publicado: (2009)

Chimeric Investigations into the Diamide Binding Site on the Lepidopteran Ryanodine Receptor
por: Richardson, Ewan, et al.
Publicado: (2021)

Role of Tryptophan 38 in Loading Substrate Chain into the Active-site Tunnel of Cellobiohydrolase I from Trichoderma reesei
por: Nakamura, Akihiko, et al.
Publicado: (2021)

Three-Dimensional Location of the Imperatoxin a Binding Site on the Ryanodine Receptor
por: Samsó, Montserrat, et al.
Publicado: (1999)

Effects of caffeine, tetracaine, and ryanodine on calcium-dependent oscillations in sheep cardiac Purkinje fibers
Publicado: (1985)

Gender Differences in the Inheritance Mode of RYR2 Mutations in Catecholaminergic Polymorphic Ventricular Tachycardia Patients
por: Ohno, Seiko, et al.
Publicado: (2015)

Correction: Gender Differences in the Inheritance Mode of RYR2 Mutations in Catecholaminergic Polymorphic Ventricular Tachycardia Patients
por: Ohno, Seiko, et al.
Publicado: (2021)

The Ca(2+) permeation mechanism of the ryanodine receptor revealed by a multi-site ion model
por: Zhang, Aihua, et al.
Publicado: (2020)

Ca(2+)-dependent calmodulin binding to cardiac ryanodine receptor (RyR2) calmodulin-binding domains
por: Brohus, Malene, et al.
Publicado: (2019)

C-terminal residues of skeletal muscle calsequestrin are essential for calcium binding and for skeletal ryanodine receptor inhibition
por: Beard, Nicole A, et al.
Publicado: (2015)

Myoplasmic resting Ca(2+) regulation by ryanodine receptors is under the control of a novel Ca(2+)-binding region of the receptor
por: Chen, Yanyi, et al.
Publicado: (2014)

Nitric Oxide-induced Activation of the Type 1 Ryanodine Receptor Is Critical for Epileptic Seizure-induced Neuronal Cell Death
por: Mikami, Yoshinori, et al.
Publicado: (2016)

Unique genetic background and outcome of non‐Caucasian Japanese probands with arrhythmogenic right ventricular dysplasia/cardiomyopathy
por: Wada, Yuko, et al.
Publicado: (2017)

Bradycardia Is a Specific Phenotype of Catecholaminergic Polymorphic Ventricular Tachycardia Induced by RYR2 Mutations
por: Miyata, Kazuaki, et al.
Publicado: (2018)

Identification of a novel exon3 deletion of RYR2 in a family with catecholaminergic polymorphic ventricular tachycardia
por: Dharmawan, Tommy, et al.
Publicado: (2019)

Mice with R2509C-RYR1 mutation exhibit dysfunctional Ca(2+) dynamics in primary skeletal myocytes
por: Tsuboi, Yoshitaka, et al.
Publicado: (2022)

Ryanoid Modification of the Cardiac Muscle Ryanodine Receptor Channel Results in Relocation of the Tetraethylammonium Binding Site
por: Tanna, Bhavna, et al.
Publicado: (2001)

Arrhythmia-Associated Calmodulin E105A Mutation Alters the Binding Affinity of CaM to a Ryanodine Receptor 2 CaM-Binding Pocket
por: Thanassoulas, Angelos, et al.
Publicado: (2023)

Molecular mechanism of the severe MH/CCD mutation Y522S in skeletal ryanodine receptor (RyR1) by cryo-EM
por: Iyer, Kavita A., et al.
Publicado: (2022)

Ryanodine receptor modulation by caffeine challenge modifies Na(+) current properties in intact murine skeletal muscle fibres
por: Sarbjit-Singh, Sahib S., et al.
Publicado: (2020)

A diminutive and specific RNA binding site for L-tryptophan
por: Majerfeld, Irene, et al.
Publicado: (2005)

Cannot write session to /tmp/vufind_sessions/sess_20374rt0g0ri3rv3q8ivn8utld