Selective cold pain inhibition by targeted block of TRPM8-expressing neurons with quaternary lidocaine derivative QX-314

Treatment of pain with local anesthetics leads to an unfavorable decrease in general sensory acuity due to their indiscriminate block of both pain sensing (nociceptors) and non-pain sensing nerves. However, the cell impermeant lidocaine derivative QX-314 can be selectively targeted to only nocicepto...

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Detalles Bibliográficos
Autores principales: Ongun, Serra, Sarkisian, Angela, McKemy, David D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6123689/
https://www.ncbi.nlm.nih.gov/pubmed/30271936
http://dx.doi.org/10.1038/s42003-018-0062-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6123689/
https://www.ncbi.nlm.nih.gov/pubmed/30271936
http://dx.doi.org/10.1038/s42003-018-0062-2

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