Metabolic surgery improves insulin resistance through the reduction of gut-secreted heat shock proteins

Metabolic surgery improves insulin resistance and is associated with the remission of type 2 diabetes, but the mechanisms involved remain unknown. We find that human jejunal mucosa secretes heat shock proteins (HSPs) in vitro, in particular HSP70 and GRP78. Circulating levels of HSP70 are higher in...

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Detalles Bibliográficos
Autores principales: Angelini, Giulia, Salinari, Serenella, Bertuzzi, Alessandro, Iaconelli, Amerigo, Mingrone, Geltrude
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6123703/
https://www.ncbi.nlm.nih.gov/pubmed/30271951
http://dx.doi.org/10.1038/s42003-018-0069-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6123703/
https://www.ncbi.nlm.nih.gov/pubmed/30271951
http://dx.doi.org/10.1038/s42003-018-0069-8

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