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Recombinant human B cell repertoires enable screening for rare, specific, and natively paired antibodies
The human antibody repertoire is increasingly being recognized as a valuable source of therapeutic grade antibodies. However, methods for mining primary antibody-expressing B cells are limited in their ability to rapidly isolate rare and antigen-specific binders. Here we show the encapsulation of tw...
Autores principales: | Rajan, Saravanan, Kierny, Michael R., Mercer, Andrew, Wu, Jincheng, Tovchigrechko, Andrey, Wu, Herren, Dall′Acqua, William F., Xiao, Xiaodong, Chowdhury, Partha S. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6123710/ https://www.ncbi.nlm.nih.gov/pubmed/30271892 http://dx.doi.org/10.1038/s42003-017-0006-2 |
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