Bioluminescence resonance energy transfer-based biosensors allow monitoring of ligand- and transducer-mediated GPCR conformational changes

G protein-coupled receptors (GPCRs) are seven-transmembrane proteins that mediate a variety of cellular response which make them a target of choice for drug development in many indications. It is now well established that GPCRs can adopt several distinct conformations that can be differentially stab...

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Detalles Bibliográficos
Autores principales: Picard, Louis-Philippe, Schönegge, Anne Marie, Lohse, Martin J., Bouvier, Michel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6123734/
https://www.ncbi.nlm.nih.gov/pubmed/30271986
http://dx.doi.org/10.1038/s42003-018-0101-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6123734/
https://www.ncbi.nlm.nih.gov/pubmed/30271986
http://dx.doi.org/10.1038/s42003-018-0101-z

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