Multiplexed deactivated CRISPR-Cas9 gene expression perturbations deter bacterial adaptation by inducing negative epistasis

The ever-increasing threat of multi-drug resistant bacteria, a shrinking antibiotic pipeline, and the innate ability of microorganisms to adapt necessitates long-term strategies to slow the evolution of antibiotic resistance. Here we develop an approach, dubbed Controlled Hindrance of Adaptation of...

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Detalles Bibliográficos
Autores principales: Otoupal, Peter B., Cordell, William T., Bachu, Vismaya, Sitton, Madeleine J., Chatterjee, Anushree
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6123780/
https://www.ncbi.nlm.nih.gov/pubmed/30272008
http://dx.doi.org/10.1038/s42003-018-0135-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6123780/
https://www.ncbi.nlm.nih.gov/pubmed/30272008
http://dx.doi.org/10.1038/s42003-018-0135-2

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