A universal bioluminescence resonance energy transfer sensor design enables high-sensitivity screening of GPCR activation dynamics

G-protein-coupled receptors (GPCRs) represent one of the most important classes of drug targets. The discovery of new GCPR therapeutics would greatly benefit from the development of a generalizable high-throughput assay to directly monitor their activation or de-activation. Here we screened a variet...

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Detalles Bibliográficos
Autores principales: Schihada, Hannes, Vandenabeele, Sylvie, Zabel, Ulrike, Frank, Monika, Lohse, Martin J., Maiellaro, Isabella
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6123785/
https://www.ncbi.nlm.nih.gov/pubmed/30271985
http://dx.doi.org/10.1038/s42003-018-0072-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6123785/
https://www.ncbi.nlm.nih.gov/pubmed/30271985
http://dx.doi.org/10.1038/s42003-018-0072-0

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