Frequent mutation of the FOXA1 untranslated region in prostate cancer

Prostate cancer has a low somatic mutation rate but non-coding regions remain underexplored. We sequenced the untranslated regions (UTRs) of 72 established driver genes in 428 patients with metastatic prostate cancer and identified FOXA1 3′-UTR mutations in 12% of patients. The mutations were predom...

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Detalles Bibliográficos
Autores principales: Annala, Matti, Taavitsainen, Sinja, Vandekerkhove, Gillian, Bacon, Jack V. W., Beja, Kevin, Chi, Kim N., Nykter, Matti, Wyatt, Alexander W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6123809/
https://www.ncbi.nlm.nih.gov/pubmed/30272002
http://dx.doi.org/10.1038/s42003-018-0128-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6123809/
https://www.ncbi.nlm.nih.gov/pubmed/30272002
http://dx.doi.org/10.1038/s42003-018-0128-1

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