Cargando…

Repurposing sertraline sensitizes non–small cell lung cancer cells to erlotinib by inducing autophagy

Lung cancer patients treated with tyrosine kinase inhibitors (TKIs) often develop resistance. More effective and safe therapeutic agents are urgently needed to overcome TKI resistance. Here, we propose a medical genetics–based approach to identify indications for over 1,000 US Food and Drug Administ...

Descripción completa

Detalles Bibliográficos
Autores principales:	Jiang, Xingwu, Lu, Weiqiang, Shen, Xiaoyang, Wang, Quan, Lv, Jing, Liu, Mingyao, Cheng, Feixiong, Zhao, Zhongming, Pang, Xiufeng
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Clinical Investigation 2018
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6124398/ https://www.ncbi.nlm.nih.gov/pubmed/29875309 http://dx.doi.org/10.1172/jci.insight.98921

Ejemplares similares

Suppression of KRas-mutant cancer through the combined inhibition of KRAS with PLK1 and ROCK
por: Wang, Jieqiong, et al.
Publicado: (2016)

Sertraline, Paroxetine, and Chlorpromazine Are Rapidly Acting Anthelmintic Drugs Capable of Clinical Repurposing
por: Weeks, Janis C., et al.
Publicado: (2018)

Identifying erlotinib-sensitive non-small cell lung carcinoma tumors in mice using [(11)C]erlotinib PET
por: Abourbeh, Galith, et al.
Publicado: (2015)

Inhibition of Autophagy Suppresses Sertraline-Mediated Primary Ciliogenesis in Retinal Pigment Epithelium Cells
por: Kim, Eun Sung, et al.
Publicado: (2015)

Effects of repurposed drug candidates nitroxoline and nelfinavir as single agents or in combination with erlotinib in pancreatic cancer cells
por: Veschi, Serena, et al.
Publicado: (2018)

Combination Erlotinib-Cisplatin and Atg3-Mediated Autophagy in Erlotinib Resistant Lung Cancer
por: Lee, Jasmine G., et al.
Publicado: (2012)

Ezrin Enhances EGFR Signaling and Modulates Erlotinib Sensitivity in Non–Small Cell Lung Cancer Cells()
por: Saygideğer-Kont, Yasemin, et al.
Publicado: (2016)

Intrinsic caspase-8 activation mediates sensitization of erlotinib-resistant tumor cells to erlotinib/cell-cycle inhibitors combination treatment
por: Orzáez, M, et al.
Publicado: (2012)

EGFR testing and erlotinib use in non-small cell lung cancer patients in Kentucky
por: Larson, Kara L., et al.
Publicado: (2020)

SERTRALINE INDUCED HYPOMANIA
por: Kumar, Ratanendra, et al.
Publicado: (2000)

Hyperamylasemia Related to Sertraline
por: Ceylan, Mehmet Emin, et al.
Publicado: (2016)

Sertraline-induced Hemichorea
por: Gatto, Emilia M., et al.
Publicado: (2017)

Ultra-small gadolinium oxide nanocrystal sensitization of non-small-cell lung cancer cells toward X-ray irradiation by promoting cytostatic autophagy
por: Li, Feifei, et al.
Publicado: (2019)

Engineering of Amphiphilic Erlotinib Analogue as Novel Nanomedicine for Non-Small Cell Lung Cancer Therapy
por: Cong, Mei, et al.
Publicado: (2023)

Inhibiting cytoplasmic accumulation of HuR synergizes genotoxic agents in urothelial carcinoma of the bladder
por: Guo, Jiawei, et al.
Publicado: (2016)

Antidepressant Drug Sertraline against Human Cancer Cells
por: Duarte, Diana, et al.
Publicado: (2022)

When Alice Took Sertraline: A Case of Sertraline-Induced Alice in Wonderland Syndrome
por: Vilela, Maria, et al.
Publicado: (2020)

PFKFB3 Inhibition Impairs Erlotinib-Induced Autophagy in NSCLCs
por: Lypova, Nadiia, et al.
Publicado: (2021)

Review of erlotinib in the treatment of advanced non-small cell lung cancer
por: Ganjoo, Kristen N, et al.
Publicado: (2007)

Artificial intelligence in COVID-19 drug repurposing
por: Zhou, Yadi, et al.
Publicado: (2020)

Sertraline exposure leads to small left heart syndrome in adult mice
por: Haskell, Sarah E., et al.
Publicado: (2012)

Sensitivity of non-small cell lung cancer to erlotinib is regulated by the Notch/miR-223/FBXW7 pathway
por: Zhang, Haiwei, et al.
Publicado: (2017)

In vitro cytogenotoxic evaluation of sertraline
por: Istifli, Erman Salih, et al.
Publicado: (2018)

Use of Sertraline in Hemodialysis Patients
por: Kubanek, Alicja, et al.
Publicado: (2021)

Monitoring sertraline and clozapine levels
por: Rodriguez Campos, A., et al.
Publicado: (2022)

Metformin sensitizes lung cancer cells to treatment by the tyrosine kinase inhibitor erlotinib
por: Wang, Xiaofei, et al.
Publicado: (2017)

Shikonin sensitizes wild-type EGFR NSCLC cells to erlotinib and gefitinib therapy
por: Li, Yang-Ling, et al.
Publicado: (2018)

LKB1 deficiency enhances sensitivity to energetic stress induced by erlotinib treatment in non-small cell lung cancer (NSCLC) cells
por: Whang, Young Mi, et al.
Publicado: (2015)

Drug Repurposing Screening Identifies Tioconazole as an ATG4 Inhibitor that Suppresses Autophagy and Sensitizes Cancer Cells to Chemotherapy
por: Liu, Pei-Feng, et al.
Publicado: (2018)

Possible cross-sensitivity between sertraline and paroxetine in a panic disorder patient
por: Khairkar, Praveen H., et al.
Publicado: (2010)

YAP promotes erlotinib resistance in human non-small cell lung cancer cells
por: Hsu, Ping-Chih, et al.
Publicado: (2016)

The Antidepressant Sertraline Affects Cell Signaling and Metabolism in Trichophyton rubrum
por: Galvão-Rocha, Flaviane M., et al.
Publicado: (2023)

TUSC2(FUS1)-erlotinib Induced Vulnerabilities in Epidermal Growth Factor Receptor(EGFR) Wildtype Non-small Cell Lung Cancer(NSCLC) Targeted by the Repurposed Drug Auranofin
por: Xiaobo, Cao, et al.
Publicado: (2016)

The pan-HDAC inhibitor panobinostat acts as a sensitizer for erlotinib activity in EGFR-mutated and -wildtype non-small cell lung cancer cells
por: Greve, Gabriele, et al.
Publicado: (2015)

Erlotinib-based doublet targeted therapy versus erlotinib alone in previously treated advanced non-small-cell lung cancer: a meta-analysis from 24 randomized controlled trials
por: Gao, Jian-Wei, et al.
Publicado: (2017)

A combination therapy for KRAS-mutant lung cancer by targeting synthetic lethal partners of mutant KRAS
por: Pang, Xiufeng, et al.
Publicado: (2016)

Defeat mutant KRAS with synthetic lethality
por: Pang, Xiufeng, et al.
Publicado: (2016)

Meta-analysis of efficacy and adverse events of erlotinib-based targeted therapies for advanced/metastatic non-small cell lung cancer
por: Li, Fei, et al.
Publicado: (2017)

Sertraline-induced pseudocholinesterase enzyme deficiency
por: Zencirci, Beyazit
Publicado: (2010)

Sertraline induced acute mandibular dystonia
por: Raveendranathan, Dhanya, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_prhq5tgdqbu4qilsiu7rm6uq8h