The role of cytochrome P450 enzymes in carcinogen activation and detoxication: an in vivo–in vitro paradox

Many chemical carcinogens require metabolic activation via xenobiotic-metabolizing enzymes in order to exert their genotoxic effects. Evidence from numerous in-vitro studies, utilizing reconstituted systems, microsomal fractions and cultured cells, implicates cytochrome P450 enzymes as being the pre...

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Detalles Bibliográficos
Autores principales: Reed, Lindsay, Arlt, Volker M, Phillips, David H
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2018
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6124610/
https://www.ncbi.nlm.nih.gov/pubmed/29726902
http://dx.doi.org/10.1093/carcin/bgy058

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6124610/
https://www.ncbi.nlm.nih.gov/pubmed/29726902
http://dx.doi.org/10.1093/carcin/bgy058

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