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The role of cytochrome P450 enzymes in carcinogen activation and detoxication: an in vivo–in vitro paradox
Many chemical carcinogens require metabolic activation via xenobiotic-metabolizing enzymes in order to exert their genotoxic effects. Evidence from numerous in-vitro studies, utilizing reconstituted systems, microsomal fractions and cultured cells, implicates cytochrome P450 enzymes as being the pre...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Oxford University Press
2018
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6124610/ https://www.ncbi.nlm.nih.gov/pubmed/29726902 http://dx.doi.org/10.1093/carcin/bgy058 |