Modal-based estimation via heterogeneity-penalized weighting: model averaging for consistent and efficient estimation in Mendelian randomization when a plurality of candidate instruments are valid

BACKGROUND: A robust method for Mendelian randomization does not require all genetic variants to be valid instruments to give consistent estimates of a causal parameter. Several such methods have been developed, including a mode-based estimation method giving consistent estimates if a plurality of g...

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Detalles Bibliográficos
Autores principales: Burgess, Stephen, Zuber, Verena, Gkatzionis, Apostolos, Foley, Christopher N
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2018
Materias:
Methods
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6124628/
https://www.ncbi.nlm.nih.gov/pubmed/29846613
http://dx.doi.org/10.1093/ije/dyy080

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6124628/
https://www.ncbi.nlm.nih.gov/pubmed/29846613
http://dx.doi.org/10.1093/ije/dyy080

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