Combining traditional 2D and modern physical organic-derived descriptors to predict enhanced enantioselectivity for the key aza-Michael conjugate addition in the synthesis of Prevymis™ (letermovir)

Quantitative structure–activity relationships have an extensive history for optimizing drug candidates, yet they have only recently been applied in reaction development. In this report, the predictive power of multivariate parameterization has been explored toward the optimization of a catalyst prom...

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Detalles Bibliográficos
Autores principales: Metsänen, Toni T., Lexa, Katrina W., Santiago, Celine B., Chung, Cheol K., Xu, Yingju, Liu, Zhijian, Humphrey, Guy R., Ruck, Rebecca T., Sherer, Edward C., Sigman, Matthew S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Royal Society of Chemistry 2018
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6124913/
https://www.ncbi.nlm.nih.gov/pubmed/30210766
http://dx.doi.org/10.1039/c8sc02089b

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6124913/
https://www.ncbi.nlm.nih.gov/pubmed/30210766
http://dx.doi.org/10.1039/c8sc02089b

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