Histamine causes endothelial barrier disruption via Ca(2+)-mediated RhoA activation and tension at adherens junctions

During inflammation, the disruption of the endothelial barrier leads to increased microvascular permeability. Whether tension along cell junctions contributes to histamine-induced endothelial barrier disruption remains unknown. Rapid Ca(2+) influx induced by both histamine and thrombin was accompani...

Descripción completa

Detalles Bibliográficos
Autores principales: Kugelmann, Daniela, Rotkopf, Lukas Thomas, Radeva, Mariya Yosifova, Garcia-Ponce, Alexander, Walter, Elias, Waschke, Jens
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6125323/
https://www.ncbi.nlm.nih.gov/pubmed/30185878
http://dx.doi.org/10.1038/s41598-018-31408-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6125323/
https://www.ncbi.nlm.nih.gov/pubmed/30185878
http://dx.doi.org/10.1038/s41598-018-31408-3

Ejemplares similares