Mapping the Interface of a GPCR Dimer: A Structural Model of the A(2A) Adenosine and D(2) Dopamine Receptor Heteromer

The A(2A) adenosine (A(2A)R) and D(2) dopamine (D(2)R) receptors form oligomers in the cell membrane and allosteric interactions across the A(2A)R–D(2)R heteromer represent a target for development of drugs against central nervous system disorders. However, understanding of the molecular determinant...

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Detalles Bibliográficos
Autores principales: Borroto-Escuela, Dasiel O., Rodriguez, David, Romero-Fernandez, Wilber, Kapla, Jon, Jaiteh, Mariama, Ranganathan, Anirudh, Lazarova, Tzvetana, Fuxe, Kjell, Carlsson, Jens
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6125358/
https://www.ncbi.nlm.nih.gov/pubmed/30214407
http://dx.doi.org/10.3389/fphar.2018.00829

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6125358/
https://www.ncbi.nlm.nih.gov/pubmed/30214407
http://dx.doi.org/10.3389/fphar.2018.00829

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