Cargando…

Mapping the Interface of a GPCR Dimer: A Structural Model of the A(2A) Adenosine and D(2) Dopamine Receptor Heteromer

The A(2A) adenosine (A(2A)R) and D(2) dopamine (D(2)R) receptors form oligomers in the cell membrane and allosteric interactions across the A(2A)R–D(2)R heteromer represent a target for development of drugs against central nervous system disorders. However, understanding of the molecular determinant...

Descripción completa

Detalles Bibliográficos
Autores principales:	Borroto-Escuela, Dasiel O., Rodriguez, David, Romero-Fernandez, Wilber, Kapla, Jon, Jaiteh, Mariama, Ranganathan, Anirudh, Lazarova, Tzvetana, Fuxe, Kjell, Carlsson, Jens
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2018
Materias:	Pharmacology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6125358/ https://www.ncbi.nlm.nih.gov/pubmed/30214407 http://dx.doi.org/10.3389/fphar.2018.00829

Ejemplares similares

Adenosine heteroreceptor complexes in the basal ganglia are implicated in Parkinson’s disease and its treatment
por: Borroto-Escuela, Dasiel O., et al.
Publicado: (2019)

On the G-Protein-Coupled Receptor Heteromers and Their Allosteric Receptor-Receptor Interactions in the Central Nervous System: Focus on Their Role in Pain Modulation
por: Borroto-Escuela, Dasiel O., et al.
Publicado: (2013)

Molecular Integration in Adenosine Heteroreceptor Complexes Through Allosteric and De-Phosphorylation (STEP) Mechanisms and its Role in Brain Disease
por: Borroto-Escuela, Dasiel O., et al.
Publicado: (2022)

On the existence and function of galanin receptor heteromers in the central nervous system
por: Fuxe, Kjell, et al.
Publicado: (2012)

Diversity and Bias through Receptor–Receptor Interactions in GPCR Heteroreceptor Complexes. Focus on Examples from Dopamine D2 Receptor Heteromerization
por: Fuxe, Kjell, et al.
Publicado: (2014)

Can Allosteric Receptor-Protein Interactions in Receptor Complexes Be a Molecular Mechanism Involved in Cancer Immune Therapy?
por: Borroto-Escuela, Dasiel O., et al.
Publicado: (2019)

Oligomeric Receptor Complexes and Their Allosteric Receptor-Receptor Interactions in the Plasma Membrane Represent a New Biological Principle for Integration of Signals in the CNS
por: Borroto-Escuela, Dasiel O., et al.
Publicado: (2019)

Multiple Adenosine-Dopamine (A2A-D2 Like) Heteroreceptor Complexes in the Brain and Their Role in Schizophrenia
por: Borroto-Escuela, Dasiel O., et al.
Publicado: (2020)

The mGlu(5) Receptor Protomer-Mediated Dopamine D(2) Receptor Trans-Inhibition Is Dependent on the Adenosine A(2A) Receptor Protomer: Implications for Parkinson’s Disease
por: Romero-Fernandez, Wilber, et al.
Publicado: (2022)

Understanding the Role of Adenosine A2AR Heteroreceptor Complexes in Neurodegeneration and Neuroinflammation
por: Borroto-Escuela, Dasiel O., et al.
Publicado: (2018)

Volume transmission and receptor-receptor interactions in heteroreceptor complexes: understanding the role of new concepts for brain communication
por: Fuxe, Kjell, et al.
Publicado: (2016)

On the G Protein-Coupled Receptor Neuromodulation of the Claustrum
por: Borroto-Escuela, Dasiel O., et al.
Publicado: (2019)

The integrative role of G protein-coupled receptor heterocomplexes in Parkinson’s disease
por: Borroto-Escuela, Dasiel O., et al.
Publicado: (2022)

Adenosine A(2A)Receptors in Substance Use Disorders: A Focus on Cocaine
por: Wydra, Karolina, et al.
Publicado: (2020)

A2AR Transmembrane 2 Peptide Administration Disrupts the A2AR-A2AR Homoreceptor but Not the A2AR-D2R Heteroreceptor Complex: Lack of Actions on Rodent Cocaine Self-Administration
por: Borroto-Escuela, Dasiel O., et al.
Publicado: (2019)

Adenosine and Kynurenic Acid Interactions: Possible Relevance for Schizophrenia Treatment?
por: Beggiato, Sarah, et al.
Publicado: (2021)

OSU-6162, a Sigma1R Ligand in Low Doses, Can Further Increase the Effects of Cocaine Self-Administration on Accumbal D2R Heteroreceptor Complexes
por: Borroto-Escuela, Dasiel O., et al.
Publicado: (2019)

Adenosine Receptor Heteromers and their Integrative Role in Striatal Function
por: Ferré, Sergi, et al.
Publicado: (2007)

The G Protein-Coupled Receptor Heterodimer Network (GPCR-HetNet) and Its Hub Components
por: Borroto-Escuela, Dasiel O., et al.
Publicado: (2014)

Potential of caveolae in the therapy of cardiovascular and neurological diseases
por: Navarro, Gemma, et al.
Publicado: (2014)

On the role of A(2A) and D(2) receptors in control of cocaine and food-seeking behaviors in rats
por: Wydra, Karolina, et al.
Publicado: (2014)

Understanding the Role of GPCR Heteroreceptor Complexes in Modulating the Brain Networks in Health and Disease
por: Borroto-Escuela, Dasiel O., et al.
Publicado: (2017)

IL1R2, CCR2, and CXCR4 May Form Heteroreceptor Complexes with NMDAR and D2R: Relevance for Schizophrenia
por: Borroto-Escuela, Dasiel O., et al.
Publicado: (2017)

Heterodimerization of Mu Opioid Receptor Protomer with Dopamine D(2) Receptor Modulates Agonist-Induced Internalization of Mu Opioid Receptor
por: Vasudevan, Lakshmi, et al.
Publicado: (2019)

Disruption of A2AR-D2R Heteroreceptor Complexes After A2AR Transmembrane 5 Peptide Administration Enhances Cocaine Self-Administration in Rats
por: Borroto-Escuela, Dasiel O., et al.
Publicado: (2018)

Evidence for the existence of dopamine D2R and Sigma 1 allosteric receptor-receptor interaction in the rat brain: role in brain plasticity and cocaine action
por: Pinton, Luca, et al.
Publicado: (2015)

Family a GPCR heteromers in animal models
por: González-Maeso, Javier
Publicado: (2014)

Differential allosteric modulation within dopamine D(2)R - neurotensin NTS1R and D(2)R - serotonin 5-HT(2A)R receptor complexes gives bias to intracellular calcium signalling
por: Plach, Michael, et al.
Publicado: (2019)

Acute Cocaine Enhances Dopamine D(2)R Recognition and Signaling and Counteracts D(2)R Internalization in Sigma1R-D(2)R Heteroreceptor Complexes
por: Borroto-Escuela, Dasiel O., et al.
Publicado: (2019)

The oxytocin receptor represents a key hub in the GPCR heteroreceptor network: potential relevance for brain and behavior
por: Borroto-Escuela, Dasiel O., et al.
Publicado: (2022)

The Balance of MU-Opioid, Dopamine D2 and Adenosine A2A Heteroreceptor Complexes in the Ventral Striatal-Pallidal GABA Antireward Neurons May Have a Significant Role in Morphine and Cocaine Use Disorders
por: Borroto-Escuela, Dasiel O., et al.
Publicado: (2021)

GPCR heteromers: An overview of their classification, function and physiological relevance
por: Dale, Natasha C., et al.
Publicado: (2022)

Performance of virtual screening against GPCR homology models: Impact of template selection and treatment of binding site plasticity
por: Jaiteh, Mariama, et al.
Publicado: (2020)

Desipramine restores the alterations in circadian entrainment induced by prenatal exposure to glucocorticoids
por: Spulber, Stefan, et al.
Publicado: (2019)

Adenosine A(2A) receptor ligand recognition and signaling is blocked by A(2B) receptors
por: Hinz, Sonja, et al.
Publicado: (2018)

Combined treatment with Sigma1R and A2AR agonists fails to inhibit cocaine self-administration despite causing strong antagonistic accumbal A2AR-D2R complex interactions: the potential role of astrocytes
por: Borroto-Escuela, Dasiel O., et al.
Publicado: (2023)

5HT1AR-FGFR1 Heteroreceptor Complexes Differently Modulate GIRK Currents in the Dorsal Hippocampus and the Dorsal Raphe Serotonin Nucleus of Control Rats and of a Genetic Rat Model of Depression
por: Ambrogini, Patrizia, et al.
Publicado: (2023)

Fragment optimization for GPCRs by molecular dynamics free energy calculations: Probing druggable subpockets of the A(2A) adenosine receptor binding site
por: Matricon, Pierre, et al.
Publicado: (2017)

Effects of intra-accumbal or intra-prefrontal cortex microinjections of adenosine 2A receptor ligands on responses to cocaine reward and seeking in rats
por: Wydra, K., et al.
Publicado: (2018)

Effects of Long‐Term Alcohol Drinking on the Dopamine D2 Receptor: Gene Expression and Heteroreceptor Complexes in the Striatum in Rats
por: Feltmann, Kristin, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_3c9b4dhe7h6hhrjeqpmhdib19l