Effects of tumor treating fields (TTFields) on glioblastoma cells are augmented by mitotic checkpoint inhibition

Tumor treating fields (TTFields) are approved for glioblastoma (GBM) therapy. TTFields disrupt cell division by inhibiting spindle fiber formation. Spindle assembly checkpoint (SAC) inhibition combined with antimitotic drugs synergistically decreases glioma cell growth in cell culture and mice. We h...

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Detalles Bibliográficos
Autores principales: Kessler, Almuth F., Frömbling, Greta E., Gross, Franziska, Hahn, Mirja, Dzokou, Wilfrid, Ernestus, Ralf-Ingo, Löhr, Mario, Hagemann, Carsten
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6125382/
https://www.ncbi.nlm.nih.gov/pubmed/30210815
http://dx.doi.org/10.1038/s41420-018-0079-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6125382/
https://www.ncbi.nlm.nih.gov/pubmed/30210815
http://dx.doi.org/10.1038/s41420-018-0079-9

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