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The DNMT3A R882H mutation does not cause dominant negative effects in purified mixed DNMT3A/R882H complexes
The DNA methyltransferase DNMT3A R882H mutation is observed in 25% of all AML patients. DNMT3A is active as tetramer and the R882H mutation is located in one of the subunit/subunit interfaces. Previous work has reported that formation of mixed wildtype/R882H complexes leads to a strong loss of catal...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6125428/ https://www.ncbi.nlm.nih.gov/pubmed/30185810 http://dx.doi.org/10.1038/s41598-018-31635-8 |