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The DNMT3A R882H mutation does not cause dominant negative effects in purified mixed DNMT3A/R882H complexes

The DNA methyltransferase DNMT3A R882H mutation is observed in 25% of all AML patients. DNMT3A is active as tetramer and the R882H mutation is located in one of the subunit/subunit interfaces. Previous work has reported that formation of mixed wildtype/R882H complexes leads to a strong loss of catal...

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Detalles Bibliográficos
Autores principales:	Emperle, Max, Dukatz, Michael, Kunert, Stefan, Holzer, Katharina, Rajavelu, Arumugam, Jurkowska, Renata Z., Jeltsch, Albert
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6125428/ https://www.ncbi.nlm.nih.gov/pubmed/30185810 http://dx.doi.org/10.1038/s41598-018-31635-8

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