Genomic and expression profiling reveal molecular heterogeneity of disseminated tumor cells in bone marrow of early breast cancer

Detection of disseminated tumor cells (DTCs) in bone marrow is an established negative prognostic factor. We isolated small pools of (~20) EPCAM-positive DTCs from early breast cancer patients for genomic profiling. Genome-wide copy number profiles of DTC pools (n = 45) appeared less aberrant than t...

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Detalles Bibliográficos
Autores principales: Magbanua, Mark Jesus M., Rugo, Hope S., Hauranieh, Louai, Roy, Ritu, Scott, Janet H., Lee, Jen Chieh, Hsiao, Feng, Sosa, Eduardo V., van’t Veer, Laura, Esserman, Laura J., Park, John W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6125436/
https://www.ncbi.nlm.nih.gov/pubmed/30211312
http://dx.doi.org/10.1038/s41523-018-0083-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6125436/
https://www.ncbi.nlm.nih.gov/pubmed/30211312
http://dx.doi.org/10.1038/s41523-018-0083-5

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