Fumarate hydratase inactivation in hereditary leiomyomatosis and renal cell cancer is synthetic lethal with ferroptosis induction

Hereditary leiomyomatosis and renal cell cancer (HLRCC) is a hereditary cancer syndrome characterized by inactivation of the Krebs cycle enzyme fumarate hydratase (FH). HLRCC patients are at high risk of developing kidney cancer of type 2 papillary morphology that is refractory to current radiothera...

Descripción completa

Detalles Bibliográficos
Autores principales: Kerins, Michael J., Milligan, John, Wohlschlegel, James A., Ooi, Aikseng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6125459/
https://www.ncbi.nlm.nih.gov/pubmed/29917289
http://dx.doi.org/10.1111/cas.13701

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6125459/
https://www.ncbi.nlm.nih.gov/pubmed/29917289
http://dx.doi.org/10.1111/cas.13701

Ejemplares similares