Ipatasertib, a novel Akt inhibitor, induces transcription factor FoxO3a and NF-κB directly regulates PUMA-dependent apoptosis

Colon cancer is one of the three common malignant tumors, with a lower survival rate. Ipatasertib, a novel highly selective ATP-competitive pan-Akt inhibitor, shows a strong antitumor effect in a variety of carcinoma, including colon cancer. However, there is a lack of knowledge about the precise un...

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Detalles Bibliográficos
Autores principales: Sun, Li, Huang, Yuan, Liu, Yeying, Zhao, Yujie, He, Xiaoxiao, Zhang, Lingling, Wang, Feng, Zhang, Yingjie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6125489/
https://www.ncbi.nlm.nih.gov/pubmed/30185800
http://dx.doi.org/10.1038/s41419-018-0943-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6125489/
https://www.ncbi.nlm.nih.gov/pubmed/30185800
http://dx.doi.org/10.1038/s41419-018-0943-9

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