Runx-dependent and silencer-independent repression of a maturation enhancer in the Cd4 gene

An intronic silencer, S4, in the Cd4 gene has been shown to be responsible for the helper-lineage-specific expression of CD4; S4 requires Runx complex binding to exert its silencer function against the enhancer-mediated Cd4 activation by modulating the epigenetic state of the Cd4 gene. Here we ident...

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Detalles Bibliográficos
Autores principales: Kojo, Satoshi, Yasmin, Nighat, Muroi, Sawako, Tenno, Mari, Taniuchi, Ichiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6125603/
https://www.ncbi.nlm.nih.gov/pubmed/30185787
http://dx.doi.org/10.1038/s41467-018-05803-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6125603/
https://www.ncbi.nlm.nih.gov/pubmed/30185787
http://dx.doi.org/10.1038/s41467-018-05803-3

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