A conserved loop–wedge motif moderates reaction site search and recognition by FEN1

DNA replication and repair frequently involve intermediate two-way junction structures with overhangs, or flaps, that must be promptly removed; a task performed by the essential enzyme flap endonuclease 1 (FEN1). We demonstrate a functional relationship between two intrinsically disordered regions o...

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Detalles Bibliográficos
Autores principales: Thompson, Mark J, Gotham, Victoria J B, Ciani, Barbara, Grasby, Jane A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2018
Materias:
Nucleic Acid Enzymes
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6125683/
https://www.ncbi.nlm.nih.gov/pubmed/29878258
http://dx.doi.org/10.1093/nar/gky506

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6125683/
https://www.ncbi.nlm.nih.gov/pubmed/29878258
http://dx.doi.org/10.1093/nar/gky506

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