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A conserved loop–wedge motif moderates reaction site search and recognition by FEN1

DNA replication and repair frequently involve intermediate two-way junction structures with overhangs, or flaps, that must be promptly removed; a task performed by the essential enzyme flap endonuclease 1 (FEN1). We demonstrate a functional relationship between two intrinsically disordered regions o...

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Detalles Bibliográficos
Autores principales:	Thompson, Mark J, Gotham, Victoria J B, Ciani, Barbara, Grasby, Jane A
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2018
Materias:	Nucleic Acid Enzymes
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6125683/ https://www.ncbi.nlm.nih.gov/pubmed/29878258 http://dx.doi.org/10.1093/nar/gky506

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