The methyltransferase domain of the Sudan ebolavirus L protein specifically targets internal adenosines of RNA substrates, in addition to the cap structure

Mononegaviruses, such as Ebola virus, encode an L (large) protein that bears all the catalytic activities for replication/transcription and RNA capping. The C-terminal conserved region VI (CRVI) of L protein contains a K-D-K-E catalytic tetrad typical for 2’O methyltransferases (MTase). In mononegav...

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Detalles Bibliográficos
Autores principales: Martin, Baptiste, Coutard, Bruno, Guez, Théo, Paesen, Guido C, Canard, Bruno, Debart, Françoise, Vasseur, Jean-Jacques, Grimes, Jonathan M, Decroly, Etienne
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2018
Materias:
Nucleic Acid Enzymes
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6125687/
https://www.ncbi.nlm.nih.gov/pubmed/30192980
http://dx.doi.org/10.1093/nar/gky637

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6125687/
https://www.ncbi.nlm.nih.gov/pubmed/30192980
http://dx.doi.org/10.1093/nar/gky637

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