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Gata4-Dependent Differentiation of c-Kit(+)–Derived Endothelial Cells Underlies Artefactual Cardiomyocyte Regeneration in the Heart

BACKGROUND: Although c-Kit(+) adult progenitor cells were initially reported to produce new cardiomyocytes in the heart, recent genetic evidence suggests that such events are exceedingly rare. However, to determine if these rare events represent true de novo cardiomyocyte formation, we deleted the n...

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Detalles Bibliográficos
Autores principales: Maliken, Bryan D., Kanisicak, Onur, Karch, Jason, Khalil, Hadi, Fu, Xing, Boyer, Justin G., Prasad, Vikram, Zheng, Yi, Molkentin, Jeffery D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6125755/
https://www.ncbi.nlm.nih.gov/pubmed/29666070
http://dx.doi.org/10.1161/CIRCULATIONAHA.118.033703