The Trem2 R47H Alzheimer’s risk variant impairs splicing and reduces Trem2 mRNA and protein in mice but not in humans

BACKGROUND: The R47H variant of the Triggering Receptor Expressed on Myeloid cells 2 (TREM2) significantly increases the risk for late onset Alzheimer’s disease. Mouse models accurately reproducing phenotypes observed in Alzheimer’ disease patients carrying the R47H coding variant are required to un...

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Detalles Bibliográficos
Autores principales: Xiang, Xianyuan, Piers, Thomas M., Wefers, Benedikt, Zhu, Kaichuan, Mallach, Anna, Brunner, Bettina, Kleinberger, Gernot, Song, Wilbur, Colonna, Marco, Herms, Jochen, Wurst, Wolfgang, Pocock, Jennifer M., Haass, Christian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6126019/
https://www.ncbi.nlm.nih.gov/pubmed/30185230
http://dx.doi.org/10.1186/s13024-018-0280-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6126019/
https://www.ncbi.nlm.nih.gov/pubmed/30185230
http://dx.doi.org/10.1186/s13024-018-0280-6

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