Site-directed mutagenesis of cysteine residues alters oxidative stability of fetal hemoglobin()

Redox active cysteine residues including βCys93 are part of hemoglobin's “oxidation hotspot”. Irreversible oxidation of βCys93 ultimately leads to the collapse of the hemoglobin structure and release of heme. Human fetal hemoglobin (HbF), similarly to the adult hemoglobin (HbA), carries redox a...

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Detalles Bibliográficos
Autores principales: Kettisen, Karin, Strader, Michael Brad, Wood, Francine, Alayash, Abdu I., Bülow, Leif
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2018
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6126208/
https://www.ncbi.nlm.nih.gov/pubmed/30193183
http://dx.doi.org/10.1016/j.redox.2018.08.010

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6126208/
https://www.ncbi.nlm.nih.gov/pubmed/30193183
http://dx.doi.org/10.1016/j.redox.2018.08.010

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