Cargando…

Site-directed mutagenesis of cysteine residues alters oxidative stability of fetal hemoglobin()

Redox active cysteine residues including βCys93 are part of hemoglobin's “oxidation hotspot”. Irreversible oxidation of βCys93 ultimately leads to the collapse of the hemoglobin structure and release of heme. Human fetal hemoglobin (HbF), similarly to the adult hemoglobin (HbA), carries redox a...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kettisen, Karin, Strader, Michael Brad, Wood, Francine, Alayash, Abdu I., Bülow, Leif
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2018
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6126208/ https://www.ncbi.nlm.nih.gov/pubmed/30193183 http://dx.doi.org/10.1016/j.redox.2018.08.010

Ejemplares similares

Dissection of the radical reactions linked to fetal hemoglobin reveals enhanced pseudoperoxidase activity
por: Ratanasopa, Khuanpiroon, et al.
Publicado: (2015)

Introducing Negatively Charged Residues on the Surface of Fetal Hemoglobin Improves Yields in Escherichia coli
por: Kettisen, Karin, et al.
Publicado: (2021)

Site-Specific Introduction of Negative Charges on the Protein Surface for Improving Global Functions of Recombinant Fetal Hemoglobin
por: Kettisen, Karin, et al.
Publicado: (2021)

Antisickling Drugs Targeting βCys93 Reduce Iron Oxidation and Oxidative Changes in Sickle Cell Hemoglobin
por: Kassa, Tigist, et al.
Publicado: (2019)

The Providence Mutation (βK82D) in Human Hemoglobin Substantially Reduces βCysteine 93 Oxidation and Oxidative Stress in Endothelial Cells
por: Jana, Sirsendu, et al.
Publicado: (2020)

Fetal hemoglobin is much less prone to DNA cleavage compared to the adult protein
por: Chakane, Sandeep, et al.
Publicado: (2017)

Structural and oxidative investigation of a recombinant high-yielding fetal hemoglobin mutant
por: Kettisen, Karin, et al.
Publicado: (2023)

Oxidative instability of hemoglobin E (β26 Glu→Lys) is increased in the presence of free α subunits and reversed by α-hemoglobin stabilizing protein (AHSP): Relevance to HbE/β-thalassemia()
por: Strader, Michael Brad, et al.
Publicado: (2016)

Substitutions in the β subunits of sickle-cell hemoglobin improve oxidative stability and increase the delay time of sickle-cell fiber formation
por: Meng, Fantao, et al.
Publicado: (2019)

Rapid Separation of Human Hemoglobin on a Large Scale From Non-clarified Bacterial Cell Homogenates Using Molecularly Imprinted Composite Cryogels
por: Hajizadeh, Solmaz, et al.
Publicado: (2021)

Post-translational modification as a response to cellular stress induced by hemoglobin oxidation in sickle cell disease
por: Strader, Michael Brad, et al.
Publicado: (2020)

Haptoglobin Preferentially Binds β but Not α Subunits Cross-Linked Hemoglobin Tetramers with Minimal Effects on Ligand and Redox Reactions
por: Jia, Yiping, et al.
Publicado: (2013)

Hemoglobin Oxidation Reactions in Stored Blood
por: Alayash, Abdu I.
Publicado: (2022)

Comparison of the oxidative reactivity of recombinant fetal and adult human hemoglobin: implications for the design of hemoglobin-based oxygen carriers
por: Simons, Michelle, et al.
Publicado: (2018)

Mechanisms of Toxicity and Modulation of Hemoglobin-based Oxygen Carriers
por: Alayash, Abdu I.
Publicado: (2019)

Changes in hemoglobin oxidation and band 3 during blood storage impact oxygen sensing and mitochondrial bioenergetic pathways in the human pulmonary arterial endothelial cell model
por: Jana, Sirsendu, et al.
Publicado: (2023)

Oxidation reactions of cellular and acellular hemoglobins: Implications for human health
por: Alayash, Abdu I.
Publicado: (2022)

Effects of α subunit substitutions on the oxidation of βCys93 and the stability of sickle cell hemoglobin
por: Hicks, Wayne, et al.
Publicado: (2020)

Hemoglobin-Based Blood Substitutes and the Treatment of Sickle Cell Disease: More Harm than Help?
por: Alayash, Abdu I.
Publicado: (2017)

Hemoglobin can Act as a (Pseudo)-Peroxidase in Vivo. What is the Evidence?
por: Alayash, Abdu I., et al.
Publicado: (2022)

Evaluation of Stem Cell-Derived Red Blood Cells as a Transfusion Product Using a Novel Animal Model
por: Shah, Sandeep N., et al.
Publicado: (2016)

Effects of Site-Directed Mutagenesis of Cysteine on the Structure of Sip Proteins
por: Wang, Lin, et al.
Publicado: (2022)

Effects of carbon monoxide (CO) delivery by a CO donor or hemoglobin on vascular hypoxia inducible factor 1α and mitochondrial respiration
por: Reiter, Chad E.N., et al.
Publicado: (2012)

Differential heme release from various hemoglobin redox states and the upregulation of cellular heme oxygenase‐1
por: Kassa, Tigist, et al.
Publicado: (2016)

Oxidative Implications of Substituting a Conserved Cysteine Residue in Sugar Beet Phytoglobin BvPgb 1.2
por: Christensen, Simon, et al.
Publicado: (2022)

Cell-Free Hemoglobin Does Not Attenuate the Effects of SARS-CoV-2 Spike Protein S1 Subunit in Pulmonary Endothelial Cells
por: Jana, Sirsendu, et al.
Publicado: (2021)

Site-Directed Mutagenesis of Gln103 Reveals the Influence of This Residue on the Redox Properties and Stability of MauG
por: Shin, Sooim, et al.
Publicado: (2014)

Oxidized Mutant Human Hemoglobins S and E Induce Oxidative Stress and Bioenergetic Dysfunction in Human Pulmonary Endothelial Cells
por: Jana, Sirsendu, et al.
Publicado: (2017)

Thiol-maleimide poly(ethylene glycol) crosslinking of L-asparaginase subunits at recombinant cysteine residues introduced by mutagenesis
por: Ramirez-Paz, Josell, et al.
Publicado: (2018)

Site-Specific Antibody Conjugation to Engineered Double Cysteine Residues
por: Zhou, Qun, et al.
Publicado: (2021)

Molecular Modeling of the Human Hemoglobin-Haptoglobin Complex Sheds Light on the Protective Mechanisms of Haptoglobin
por: Nantasenamat, Chanin, et al.
Publicado: (2013)

Engineering tyrosine residues into hemoglobin enhances heme reduction, decreases oxidative stress and increases vascular retention of a hemoglobin based blood substitute
por: Cooper, Chris E., et al.
Publicado: (2019)

Identification of Critical Residues of the Mycobacterial Dephosphocoenzyme A Kinase by Site-Directed Mutagenesis
por: Walia, Guneet, et al.
Publicado: (2011)

Identification of essential residues in potyvirus proteinase HC-pro by site-directed mutagenesis
por: Oh, Chan-Seok, et al.
Publicado: (1989)

Roles of conserved active site residues in the IscS cysteine desulfurase reaction
por: Pang, Yilin, et al.
Publicado: (2023)

Hemoglobin Cleavage Site-Specificity of the Plasmodium falciparum Cysteine Proteases Falcipain-2 and Falcipain-3
por: Subramanian, Shoba, et al.
Publicado: (2009)

Targeting the red cell enzyme pyruvate kinase with a small allosteric molecule AG-348 may correct underlying pathology of a glycolytic enzymopathy
por: Alayash, Abdu I.
Publicado: (2021)

The Impact of COVID-19 Infection on Oxygen Homeostasis: A Molecular Perspective
por: Alayash, Abdu I.
Publicado: (2021)

Complete cysteine-scanning mutagenesis of the Salmonella typhimurium melibiose permease
por: Markham, Kelsey J., et al.
Publicado: (2021)

Site Directed Mutagenesis of Amino Acid Residues at the Active Site of Mouse Aldehyde Oxidase AOX1
por: Schumann, Silvia, et al.
Publicado: (2009)

Cannot write session to /tmp/vufind_sessions/sess_pgckigug2hghfo255joopk6qds