An intestinal stem cell niche in Apc mutated neoplasia targetable by CtBP inhibition

C-terminal binding protein 2 (CtBP2) drives intestinal polyposis in the Apc (min) mouse model of human Familial Adenomatous Polyposis. As CtBP2 is targetable by an inhibitor of its dehydrogenase domain, understanding CtBP2’s role in adenoma formation is necessary to optimize CtBP-targeted therapies...

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Detalles Bibliográficos
Autores principales: Chawla, Ayesha T., Cororaton, Agnes D., Idowu, Michael O., Damle, Priyadarshan K., Szomju, Barbara, Ellis, Keith C., Patel, Bhaumik B., Grossman, Steven R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2018
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6126694/
https://www.ncbi.nlm.nih.gov/pubmed/30197752
http://dx.doi.org/10.18632/oncotarget.25784

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6126694/
https://www.ncbi.nlm.nih.gov/pubmed/30197752
http://dx.doi.org/10.18632/oncotarget.25784

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