Deep mutational scanning of hemagglutinin helps predict evolutionary fates of human H3N2 influenza variants

Human influenza virus rapidly accumulates mutations in its major surface protein hemagglutinin (HA). The evolutionary success of influenza virus lineages depends on how these mutations affect HA’s functionality and antigenicity. Here we experimentally measure the effects on viral growth in cell cult...

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Detalles Bibliográficos
Autores principales: Lee, Juhye M., Huddleston, John, Doud, Michael B., Hooper, Kathryn A., Wu, Nicholas C., Bedford, Trevor, Bloom, Jesse D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2018
Materias:
PNAS Plus
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6126756/
https://www.ncbi.nlm.nih.gov/pubmed/30104379
http://dx.doi.org/10.1073/pnas.1806133115

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6126756/
https://www.ncbi.nlm.nih.gov/pubmed/30104379
http://dx.doi.org/10.1073/pnas.1806133115

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