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Deep mutational scanning of hemagglutinin helps predict evolutionary fates of human H3N2 influenza variants
Human influenza virus rapidly accumulates mutations in its major surface protein hemagglutinin (HA). The evolutionary success of influenza virus lineages depends on how these mutations affect HA’s functionality and antigenicity. Here we experimentally measure the effects on viral growth in cell cult...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
National Academy of Sciences
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6126756/ https://www.ncbi.nlm.nih.gov/pubmed/30104379 http://dx.doi.org/10.1073/pnas.1806133115 |