The uterine epithelial loss of Pten is inefficient to induce endometrial cancer with intact stromal Pten

Mutation of the tumor suppressor Pten often leads to tumorigenesis in various organs including the uterus. We previously showed that Pten deletion in the mouse uterus using a Pgr-Cre driver (Pten(f/f)Pgr(Cre/+)) results in rapid development of endometrial carcinoma (EMC) with full penetration. We al...

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Detalles Bibliográficos
Autores principales: Liang, Xiaohuan, Daikoku, Takiko, Terakawa, Jumpei, Ogawa, Yuya, Joshi, Ayesha R., Ellenson, Lora H., Sun, Xiaofei, Dey, Sudhansu K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6126871/
https://www.ncbi.nlm.nih.gov/pubmed/30142194
http://dx.doi.org/10.1371/journal.pgen.1007630

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6126871/
https://www.ncbi.nlm.nih.gov/pubmed/30142194
http://dx.doi.org/10.1371/journal.pgen.1007630

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