The subclonal complexity of STIL-TAL1+ T-cell acute lymphoblastic leukaemia

Single-cell genetics were used to interrogate clonal complexity and the sequence of mutational events in STIL-TAL1+ T-ALL. Single-cell multicolour FISH was used to demonstrate that the earliest detectable leukaemia subclone contained the STIL-TAL1 fusion and copy number loss of 9p21.3 (CDKN2A/CDKN2B...

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Detalles Bibliográficos
Autores principales: Furness, Caroline L, Mansur, Marcela B, Weston, Victoria J, Ermini, Luca, van Delft, Frederik W, Jenkinson, Sarah, Gale, Rosemary, Harrison, Christine J, Pombo-de-Oliveira, Maria S, Sanchez-Martin, Marta, Ferrando, Adolfo A, Kearns, Pamela, Titley, Ian, Ford, Anthony M, Potter, Nicola E, Greaves, Mel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6127084/
https://www.ncbi.nlm.nih.gov/pubmed/29556024
http://dx.doi.org/10.1038/s41375-018-0046-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6127084/
https://www.ncbi.nlm.nih.gov/pubmed/29556024
http://dx.doi.org/10.1038/s41375-018-0046-8

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