Distinct roles for phosphoinositide 3-kinases γ and δ in malignant B cell migration

The PI 3-kinases (PI3K) are essential mediators of chemokine receptor signaling necessary for migration of chronic lymphocytic leukemia (CLL) cells and their interaction with tissue-resident stromal cells. While the PI3Kδ-specific inhibitor idelalisib shows efficacy in treatment of CLL and other B c...

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Detalles Bibliográficos
Autores principales: Ali, Ahmed Y., Wu, Xun, Eissa, Nour, Hou, Sen, Ghia, Jean-Eric, Murooka, Thomas T., Banerji, Versha, Johnston, James B., Lin, Francis, Gibson, Spencer B., Marshall, Aaron J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6127087/
https://www.ncbi.nlm.nih.gov/pubmed/29479062
http://dx.doi.org/10.1038/s41375-018-0012-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6127087/
https://www.ncbi.nlm.nih.gov/pubmed/29479062
http://dx.doi.org/10.1038/s41375-018-0012-5

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