Apolipoprotein A-IV binds αIIbβ3 integrin and inhibits thrombosis

Platelet αIIbβ3 integrin and its ligands are essential for thrombosis and hemostasis, and play key roles in myocardial infarction and stroke. Here we show that apolipoprotein A-IV (apoA-IV) can be isolated from human blood plasma using platelet β3 integrin-coated beads. Binding of apoA-IV to platele...

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Detalles Bibliográficos
Autores principales: Xu, Xiaohong Ruby, Wang, Yiming, Adili, Reheman, Ju, Lining, Spring, Christopher M., Jin, Joseph Wuxun, Yang, Hong, Neves, Miguel A. D., Chen, Pingguo, Yang, Yan, Lei, Xi, Chen, Yunfeng, Gallant, Reid C., Xu, Miao, Zhang, Hailong, Song, Jina, Ke, Peifeng, Zhang, Dan, Carrim, Naadiya, Yu, Si-Yang, Zhu, Guangheng, She, Yi-Min, Cyr, Terry, Fu, Wenbin, Liu, Guoqing, Connelly, Philip W., Rand, Margaret L., Adeli, Khosrow, Freedman, John, Lee, Jeffrey E., Tso, Patrick, Marchese, Patrizia, Davidson, W. Sean, Jackson, Shaun P., Zhu, Cheng, Ruggeri, Zaverio M., Ni, Heyu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6127106/
https://www.ncbi.nlm.nih.gov/pubmed/30190457
http://dx.doi.org/10.1038/s41467-018-05806-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6127106/
https://www.ncbi.nlm.nih.gov/pubmed/30190457
http://dx.doi.org/10.1038/s41467-018-05806-0

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