Fumarate hydratase loss promotes mitotic entry in the presence of DNA damage after ionising radiation

An altered response to DNA damage is commonly associated with genomic instability, a hallmark of cancer. Fumarate hydratase (FH) was recently characterised as a DNA repair factor required in non-homologous end-joining (NHEJ) through the local production of fumarate. Inactivating germline mutations i...

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Detalles Bibliográficos
Autores principales: Johnson, Timothy I., Costa, Ana S. H., Ferguson, Ashley N., Frezza, Christian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6127199/
https://www.ncbi.nlm.nih.gov/pubmed/30190474
http://dx.doi.org/10.1038/s41419-018-0912-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6127199/
https://www.ncbi.nlm.nih.gov/pubmed/30190474
http://dx.doi.org/10.1038/s41419-018-0912-3

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