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Fumarate hydratase loss promotes mitotic entry in the presence of DNA damage after ionising radiation
An altered response to DNA damage is commonly associated with genomic instability, a hallmark of cancer. Fumarate hydratase (FH) was recently characterised as a DNA repair factor required in non-homologous end-joining (NHEJ) through the local production of fumarate. Inactivating germline mutations i...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Nature Publishing Group UK
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6127199/ https://www.ncbi.nlm.nih.gov/pubmed/30190474 http://dx.doi.org/10.1038/s41419-018-0912-3 |