MEK inhibitors induce apoptosis via FoxO3a-dependent PUMA induction in colorectal cancer cells

Mutations in BRAF are common to many cancers, including CRC. The MEK inhibitors are being investigated in BRAF-mutant CRC. In this study, we aimed to investigate how MEK inhibitor suppresses growth of BRAF-mutated CRC cells as well as its potential mechanisms. Our findings indicated that MEK inhibit...

Descripción completa

Detalles Bibliográficos
Autores principales: Lin, Lin, Ding, Dapeng, Jiang, Yanmei, Li, Yan, Li, Shijun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6127344/
https://www.ncbi.nlm.nih.gov/pubmed/30190455
http://dx.doi.org/10.1038/s41389-018-0078-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6127344/
https://www.ncbi.nlm.nih.gov/pubmed/30190455
http://dx.doi.org/10.1038/s41389-018-0078-y

Ejemplares similares