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MEK inhibitors induce apoptosis via FoxO3a-dependent PUMA induction in colorectal cancer cells
Mutations in BRAF are common to many cancers, including CRC. The MEK inhibitors are being investigated in BRAF-mutant CRC. In this study, we aimed to investigate how MEK inhibitor suppresses growth of BRAF-mutated CRC cells as well as its potential mechanisms. Our findings indicated that MEK inhibit...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6127344/ https://www.ncbi.nlm.nih.gov/pubmed/30190455 http://dx.doi.org/10.1038/s41389-018-0078-y |