GSK-3β Inhibitor Alsterpaullone Attenuates MPP(+)-Induced Cell Damage in a c-Myc-Dependent Manner in SH-SY5Y Cells

Mitochondrial dysfunction plays significant roles in the pathogenesis of Parkinson’s Disease (PD). The inactivation of c-Myc, a down-stream gene of Wnt/β-catenin signaling, may contribute to the mitochondria dysfunction. Inhibition of glycogen synthase kinase 3β (GSK-3β) with Alsterpaullone (Als) ca...

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Detalles Bibliográficos
Autores principales: Wang, Jiancai, Li, Yuqian, Gao, Li, Yan, Fengqi, Gao, Guodong, Li, Lihong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6127625/
https://www.ncbi.nlm.nih.gov/pubmed/30233322
http://dx.doi.org/10.3389/fncel.2018.00283

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6127625/
https://www.ncbi.nlm.nih.gov/pubmed/30233322
http://dx.doi.org/10.3389/fncel.2018.00283

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