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Long non-coding RNAs involved in metastasis of gastric cancer

Gastric cancer (GC) is one of the most frequently diagnosed malignant diseases. The molecular mechanisms of metastasis remain unclear. Recently, studies have shown that long non-coding RNAs (lncRNAs) play critical roles in metastasis. Therefore, deeper understanding of this mechanism could provide p...

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Autores principales: Lin, Meng-Ting, Song, Hao-Jun, Ding, Xiao-Yun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Baishideng Publishing Group Inc 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6127659/
https://www.ncbi.nlm.nih.gov/pubmed/30197478
http://dx.doi.org/10.3748/wjg.v24.i33.3724
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author Lin, Meng-Ting
Song, Hao-Jun
Ding, Xiao-Yun
author_facet Lin, Meng-Ting
Song, Hao-Jun
Ding, Xiao-Yun
author_sort Lin, Meng-Ting
collection PubMed
description Gastric cancer (GC) is one of the most frequently diagnosed malignant diseases. The molecular mechanisms of metastasis remain unclear. Recently, studies have shown that long non-coding RNAs (lncRNAs) play critical roles in metastasis. Therefore, deeper understanding of this mechanism could provide potential diagnostic tools and therapeutic targets for metastatic GC. This review focuses on dysregulated lncRNAs in GC metastases. Due to the identification of multiple diverse mechanisms involved in GC metastasis, we classified them into seven categories, including lncRNAs related to epithelial-mesenchymal transition, regulation of degradation of extracellular matrix, angiopoiesis, vasculogenic mimicry, and immunologic escape. As the TNM stage is pivotal for evaluating the severity and prognosis of GC patients, we summarize the lncRNAs relevant to lymphatic metastasis, distant metastasis and TNM classification. This review summarizes the lncRNAs related to metastasis, which may provide insight into the mechanisms, and provide potential markers for prognostic prediction and monitoring the relapse of GC.
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spelling pubmed-61276592018-09-07 Long non-coding RNAs involved in metastasis of gastric cancer Lin, Meng-Ting Song, Hao-Jun Ding, Xiao-Yun World J Gastroenterol Review Gastric cancer (GC) is one of the most frequently diagnosed malignant diseases. The molecular mechanisms of metastasis remain unclear. Recently, studies have shown that long non-coding RNAs (lncRNAs) play critical roles in metastasis. Therefore, deeper understanding of this mechanism could provide potential diagnostic tools and therapeutic targets for metastatic GC. This review focuses on dysregulated lncRNAs in GC metastases. Due to the identification of multiple diverse mechanisms involved in GC metastasis, we classified them into seven categories, including lncRNAs related to epithelial-mesenchymal transition, regulation of degradation of extracellular matrix, angiopoiesis, vasculogenic mimicry, and immunologic escape. As the TNM stage is pivotal for evaluating the severity and prognosis of GC patients, we summarize the lncRNAs relevant to lymphatic metastasis, distant metastasis and TNM classification. This review summarizes the lncRNAs related to metastasis, which may provide insight into the mechanisms, and provide potential markers for prognostic prediction and monitoring the relapse of GC. Baishideng Publishing Group Inc 2018-09-07 2018-09-07 /pmc/articles/PMC6127659/ /pubmed/30197478 http://dx.doi.org/10.3748/wjg.v24.i33.3724 Text en ©The Author(s) 2018. Published by Baishideng Publishing Group Inc. All rights reserved. http://creativecommons.org/licenses/by-nc/4.0/ This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial.
spellingShingle Review
Lin, Meng-Ting
Song, Hao-Jun
Ding, Xiao-Yun
Long non-coding RNAs involved in metastasis of gastric cancer
title Long non-coding RNAs involved in metastasis of gastric cancer
title_full Long non-coding RNAs involved in metastasis of gastric cancer
title_fullStr Long non-coding RNAs involved in metastasis of gastric cancer
title_full_unstemmed Long non-coding RNAs involved in metastasis of gastric cancer
title_short Long non-coding RNAs involved in metastasis of gastric cancer
title_sort long non-coding rnas involved in metastasis of gastric cancer
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6127659/
https://www.ncbi.nlm.nih.gov/pubmed/30197478
http://dx.doi.org/10.3748/wjg.v24.i33.3724
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