mitoTev‐TALE: a monomeric DNA editing enzyme to reduce mutant mitochondrial DNA levels

Pathogenic mitochondrial DNA (mtDNA) mutations often co‐exist with wild‐type molecules (mtDNA heteroplasmy). Phenotypes manifest when the percentage of mutant mtDNA is high (70–90%). Previously, our laboratory showed that mitochondria‐targeted transcription activator‐like effector nucleases (mitoTAL...

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Detalles Bibliográficos
Autores principales: Pereira, Claudia V, Bacman, Sandra R, Arguello, Tania, Zekonyte, Ugne, Williams, Sion L, Edgell, David R, Moraes, Carlos T
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6127889/
https://www.ncbi.nlm.nih.gov/pubmed/30012581
http://dx.doi.org/10.15252/emmm.201708084

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6127889/
https://www.ncbi.nlm.nih.gov/pubmed/30012581
http://dx.doi.org/10.15252/emmm.201708084

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