Arhalofenate acid inhibits monosodium urate crystal-induced inflammatory responses through activation of AMP-activated protein kinase (AMPK) signaling

BACKGROUND: Arhalofenate acid, the active acid form of arhalofenate, is a non-agonist peroxisome proliferator-activated receptor γ (PPARγ) ligand, with uricosuric activity via URAT1 inhibition. Phase II studies revealed decreased acute arthritis flares in arhalofenate-treated gout compared with allo...

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Detalles Bibliográficos
Autores principales: McWherter, Charles, Choi, Yun-Jung, Serrano, Ramon L., Mahata, Sushil K., Terkeltaub, Robert, Liu-Bryan, Ru
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6127987/
https://www.ncbi.nlm.nih.gov/pubmed/30189890
http://dx.doi.org/10.1186/s13075-018-1699-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6127987/
https://www.ncbi.nlm.nih.gov/pubmed/30189890
http://dx.doi.org/10.1186/s13075-018-1699-4

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