Cargando…

Arhalofenate acid inhibits monosodium urate crystal-induced inflammatory responses through activation of AMP-activated protein kinase (AMPK) signaling

BACKGROUND: Arhalofenate acid, the active acid form of arhalofenate, is a non-agonist peroxisome proliferator-activated receptor γ (PPARγ) ligand, with uricosuric activity via URAT1 inhibition. Phase II studies revealed decreased acute arthritis flares in arhalofenate-treated gout compared with allo...

Descripción completa

Detalles Bibliográficos
Autores principales:	McWherter, Charles, Choi, Yun-Jung, Serrano, Ramon L., Mahata, Sushil K., Terkeltaub, Robert, Liu-Bryan, Ru
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2018
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6127987/ https://www.ncbi.nlm.nih.gov/pubmed/30189890 http://dx.doi.org/10.1186/s13075-018-1699-4

Ejemplares similares

Monosodium Urate Crystals Activate the Inflammasome in Primary Progressive Multiple Sclerosis
por: Piancone, Federica, et al.
Publicado: (2018)

Monosodium urate crystals induce oxidative stress in human synoviocytes
por: Zamudio-Cuevas, Yessica, et al.
Publicado: (2016)

The Role of Inhibitory Receptors in Monosodium Urate Crystal-Induced Inflammation
por: Fernandes, Maria J., et al.
Publicado: (2018)

Cynarin suppresses gouty arthritis induced by monosodium urate crystals
por: Wu, Changgui, et al.
Publicado: (2022)

A Randomized, Double‐Blind, Active‐ and Placebo‐Controlled Efficacy and Safety Study of Arhalofenate for Reducing Flare in Patients With Gout
por: Poiley, Jeffrey, et al.
Publicado: (2016)

Raman Spectroscopy Applied to the Noninvasive Detection of Monosodium Urate Crystal Deposits
por: Curran, Declan J, et al.
Publicado: (2015)

Monosodium Urate Crystal-Induced Chondrocyte Death via Autophagic Process
por: Hwang, Hyun Sook, et al.
Publicado: (2015)

Factors influencing the crystallization of monosodium urate: a systematic literature review
por: Chhana, Ashika, et al.
Publicado: (2015)

Osteogenic Potential of Monosodium Urate Crystals in Synovial Mesenchymal Stem Cells
por: Martínez-Flores, Karina, et al.
Publicado: (2022)

Lower Temperatures Exacerbate NLRP3 Inflammasome Activation by Promoting Monosodium Urate Crystallization, Causing Gout
por: Ahn, Huijeong, et al.
Publicado: (2021)

Bonding the foe – NETting neutrophils immobilize the pro-inflammatory monosodium urate crystals
por: Schorn, Christine, et al.
Publicado: (2012)

The Inhibition of Osteoblast Viability by Monosodium Urate Crystal-Stimulated Neutrophil-Derived Exosomes
por: Jia, Ertao, et al.
Publicado: (2022)

Linked decreases in liver kinase B1 and AMP-activated protein kinase activity modulate matrix catabolic responses to biomechanical injury in chondrocytes
por: Petursson, Freyr, et al.
Publicado: (2013)

Uricase-Deficient Larval Zebrafish with Elevated Urate Levels Demonstrate Suppressed Acute Inflammatory Response to Monosodium Urate Crystals and Prolonged Crystal Persistence
por: Linnerz, Tanja, et al.
Publicado: (2022)

Effects of Mollugo pentaphylla extract on monosodium urate crystal-induced gouty arthritis in mice
por: Lee, Yun Mi, et al.
Publicado: (2017)

Monosodium Urate in the Presence of RANKL Promotes Osteoclast Formation through Activation of c-Jun N-Terminal Kinase
por: Choe, Jung-Yoon, et al.
Publicado: (2015)

Professional test-driven development with C#: developing real world applications with TDD
por: Bender, James, et al.
Publicado: (2011)

Testing ASP
por: McWherter, Jeff, et al.
Publicado: (2009)

Professional mobile application development
por: McWherter, Jeff, et al.
Publicado: (2012)

Monosodium urate crystals induce extracellular DNA traps in neutrophils, eosinophils, and basophils but not in mononuclear cells
por: Schorn, Christine, et al.
Publicado: (2012)

Therapeutic effects of sesame oil on monosodium urate crystal-induced acute inflammatory response in rats
por: Hsu, Dur-Zong, et al.
Publicado: (2013)

Invariant Natural Killer T Cells Ameliorate Monosodium Urate Crystal-Induced Gouty Inflammation in Mice
por: Wang, Jie, et al.
Publicado: (2017)

Presence of monosodium urate crystal deposition by dual-energy CT in patients with gout treated with allopurinol
por: Dalbeth, Nicola, et al.
Publicado: (2018)

Identification of monosodium urate crystal deposits in patients with asymptomatic hyperuricemia using dual-energy CT
por: Wang, Penny, et al.
Publicado: (2018)

Detection of intracellular monosodium urate crystals in gout synovial fluid using optical diffraction tomography
por: Park, Sangwoo, et al.
Publicado: (2021)

The application of a novel hydrodynamic cavitation device to debride intra-articular monosodium urate crystals
por: Xu, Hanlin, et al.
Publicado: (2023)

Sirt3 improves monosodium urate crystal-induced inflammation by suppressing Acod1 expression
por: Lv, Linxi, et al.
Publicado: (2023)

Protocol for in vivo and in vitro activation of NLRP3 inflammasome in mice using monosodium urate
por: Liu, Didi, et al.
Publicado: (2023)

Association of Specific Comorbidities with Monosodium Urate Crystal Deposition in Urate-Lowering Therapy-Naive Gout Patients: A Cross-Sectional Dual-Energy Computed Tomography Study
por: Pascart, Tristan, et al.
Publicado: (2020)

Monosodium Urate Contributes to Retinal Inflammation and Progression of Diabetic Retinopathy
por: Thounaojam, Menaka C., et al.
Publicado: (2019)

A novel role for monosodium urate monohydrate crystals and gouty synovial fluids in monocyte migration in gout
por: Amin, M Asif, et al.
Publicado: (2012)

Effects of Extract from Mangifera indica Leaf on Monosodium Urate Crystal-Induced Gouty Arthritis in Rats
por: Jiang, Yan, et al.
Publicado: (2012)

In Vivo Transmigrated Human Neutrophils Are Highly Primed for Intracellular Radical Production Induced by Monosodium Urate Crystals
por: Davidsson, Lisa, et al.
Publicado: (2020)

In situ Synthesized Monosodium Urate Crystal Enhances Endometrium Decidualization via Sterile Inflammation During Pregnancy
por: Zhu, Yu-Yuan, et al.
Publicado: (2021)

Downregulation of Sox8 mediates monosodium urate crystal-induced autophagic impairment of cartilage in gout arthritis
por: Xiao, Lu, et al.
Publicado: (2023)

Kv1.5 channel mediates monosodium urate-induced activation of NLRP3 inflammasome in macrophages and arrhythmogenic effects of urate on cardiomyocytes
por: Li, Peili, et al.
Publicado: (2022)

AMP-Activated Protein Kinase (AMPK) and Energy-Sensing in the Brain
por: Ramamurthy, Santosh, et al.
Publicado: (2012)

Roles of AMP-Activated Protein Kinase (AMPK) in Mammalian Reproduction
por: Yang, Weina, et al.
Publicado: (2020)

Monosodium urate crystal induced macrophage inflammation is attenuated by chondroitin sulphate: pre-clinical model for gout prophylaxis?
por: Orlowsky, Eric W, et al.
Publicado: (2014)

Effects of RuPeng15 Powder (RPP15) on Monosodium Urate Crystal-Induced Gouty Arthritis in Rats
por: Kou, Y.-Y., et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_b2d0pjrgmln7hq0dbkmeq1qhq5