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Elevated contextual fear memory by SIRT6 depletion in excitatory neurons of mouse forebrain

A class of NAD-dependent protein deacetylases, the Sirtuin (SIRT) family of proteins is involved in aging, cell survival, and neurodegeneration. Recently, SIRT proteins, including SIRT6, have been reported to be important in learning and memory. However, the role of SIRT6 in excitatory brain neurons...

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Detalles Bibliográficos
Autores principales: Kim, Hyopil, Kim, Hyun-Seok, Kaang, Bong-Kiun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6127998/
https://www.ncbi.nlm.nih.gov/pubmed/30189861
http://dx.doi.org/10.1186/s13041-018-0391-6