Genome-wide polygenic scores for common diseases identify individuals with risk equivalent to monogenic mutations

A key public health need is to identify individuals at high risk for a given disease to enable enhanced screening or preventive therapies. Because most common diseases have a genetic component, one important approach is to stratify individuals based on inherited DNA variation.(1) Proposed clinical a...

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Detalles Bibliográficos
Autores principales: Khera, Amit V., Chaffin, Mark, Aragam, Krishna G., Haas, Mary E., Roselli, Carolina, Choi, Seung Hoan, Natarajan, Pradeep, Lander, Eric S., Lubitz, Steven A., Ellinor, Patrick T., Kathiresan, Sekar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6128408/
https://www.ncbi.nlm.nih.gov/pubmed/30104762
http://dx.doi.org/10.1038/s41588-018-0183-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6128408/
https://www.ncbi.nlm.nih.gov/pubmed/30104762
http://dx.doi.org/10.1038/s41588-018-0183-z

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