Virtual screening using covalent docking to find activators for G245S mutant p53

TP53 is the most mutated gene in all cancers. The mutant protein also accumulates in cells. The high frequency of p53 mutations makes the protein a promising target for anti-cancer therapy. Only a few molecules have been found, using in vitro screening, to reactivate the mutant protein. APR-246 is c...

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Detalles Bibliográficos
Autores principales: Omar, Sara Ibrahim, Lepre, Marco Gaetano, Morbiducci, Umberto, Deriu, Marco Agostino, Tuszynski, Jack A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6128461/
https://www.ncbi.nlm.nih.gov/pubmed/30192754
http://dx.doi.org/10.1371/journal.pone.0200769

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6128461/
https://www.ncbi.nlm.nih.gov/pubmed/30192754
http://dx.doi.org/10.1371/journal.pone.0200769

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