tp53 deficiency causes a wide tumor spectrum and increases embryonal rhabdomyosarcoma metastasis in zebrafish

The TP53 tumor-suppressor gene is mutated in >50% of human tumors and Li-Fraumeni patients with germ line inactivation are predisposed to developing cancer. Here, we generated tp53 deleted zebrafish that spontaneously develop malignant peripheral nerve-sheath tumors, angiosarcomas, germ cell tumo...

Descripción completa

Detalles Bibliográficos
Autores principales: Ignatius, Myron S, Hayes, Madeline N, Moore, Finola E, Tang, Qin, Garcia, Sara P, Blackburn, Patrick R, Baxi, Kunal, Wang, Long, Jin, Alexander, Ramakrishnan, Ashwin, Reeder, Sophia, Chen, Yidong, Nielsen, Gunnlaugur Petur, Chen, Eleanor Y, Hasserjian, Robert P, Tirode, Franck, Ekker, Stephen C, Langenau, David M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2018
Materias:
Cancer Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6128690/
https://www.ncbi.nlm.nih.gov/pubmed/30192230
http://dx.doi.org/10.7554/eLife.37202

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6128690/
https://www.ncbi.nlm.nih.gov/pubmed/30192230
http://dx.doi.org/10.7554/eLife.37202

Ejemplares similares